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Абсолютное количество Т- и В-лимфоцитов у новорожденных
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Абсолютное количество Т- и В-лимфоцитов у новорожденных

Warning: file_put_contents(): Only 0 of 1308 bytes written, possibly out of free disk space in /var/www/filosof/data/www/medservices.info/wp-content/plugins/wp-optimize-by-xtraffic/Application/Service/PepVN_Cache.php on line 684 Warning: file_put_contents(): Only 0 of 128 bytes written, possibly out of free disk space in /var/www/filosof/data/www/medservices.info/wp-content/plugins/wp-optimize-by-xtraffic/Application/Service/PepVN_Cache.php on line 684 Warning: file_put_contents(): Only 0 of 115 bytes written, possibly out of free disk space in /var/www/filosof/data/www/medservices.info/wp-content/plugins/wp-optimize-by-xtraffic/Application/Service/PepVN_Cache.php on line 684 Warning: file_put_contents(): Only 0 of 128 bytes written, possibly out of free disk space in /var/www/filosof/data/www/medservices.info/wp-content/plugins/wp-optimize-by-xtraffic/Application/Service/PepVN_Cache.php on line 684 Warning: file_put_contents(): Only 0 of 110 bytes written, possibly out of free disk 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by admin01.09.2015
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По данным G. Poccardi и соавт., общее количество Т-лимфоцитов в периферической крови при исследованиях с использованием моноклональных антител Leu у новорожденных даже выше, чем у взрослых, как в абсолютных, так и в относительных величинах. При этом соотношение лимфоцитов — хелперов и супрессоров увеличено вследствие количественного преобладания Т-хелперов. 15- 20% клеток имеют двойные эпитопы — и хелперов, и супрессоров. Авторы отметили очень низкое содержание в крови естественных киллеров, тогда как у взрослых более 16%.

Преобладание Т-лимфоцитов хелперов в крови новорожденных при использовании моноклональных антител отмечено многими авторами. Это не увязывается с общей супрессорной направленностью реакций клеток иммунной системы, обнаруживаемой при функциональных исследованиях. Противоречие в расхождении фенотипов и функций Т-лимфоцитов новорожденных объясняется следующим образом.

Супрессорную функцию осуществляют не только клетки CD8, но и другие, в частности циркулирующие в крови незрелые тимоциты с маркерами CD1, CD10, CD11, а также естественные киллеры. Лимфоциты СВ4-хелперы включают активный субклон CD4/2H4, так называемые хелперы-индукторы супрессии. Выше отмечена возможность носительства клетками двойных эпитопов — хелперов и супрессоров, что затрудняет точную количественную оценку соотношения функциональных субпопуляций Т-лимфоцитов. Наконец, В-лимфоциты новорожденных отличаются низкой чувствительностью к интерлейкинам, продуцируемым хелперами.

Р. К. Kotylo и соавт. показали, что среди хелперной популяции пуповинной крови супрессии CD4/2H4 или CD4/CD45 были преобладающей фракцией лимфоцитов, тогда как клетки-хелперы, несущие маркеры CD4/4B4, составляли всего 9%. Хелперы-индукторы супрессии CD4/2H4 стимулируют функции Т-супрессоров и слабо реагируют на антигены. Субклон CD4/3B4, как известно, включает хелперы-индукторы, стимулирующие В-лимфоциты и способствующие формированию клеток, несущих иммунологическую память, но их мало у новорожденных. Некоторые лимфоциты-супрессоры CD8 у новорожденных не имеют общего для Т-лимфоцитов эпитопа CD3, поэтому не выявляются при исследовании общего числа Т-лимфоцитов.

Биологический смысл общей супрессорной направленности реакций клеток иммунной системы состоит в предупреждении тяжелой иммунокомплексной патологии при контакте с огромным числом антигенов после рождения и интенсивного развития субпопуляций лимфоцитов-хелперов, необходимого для начала синтеза собственных антител.

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